In the 1930s, while Mary Anne Trump was living with her sister in Queens, she met Fred Trump at a party. On April 5, 1937, she gave birth to their first child, Maryanne Trump Barry, followed by Frederick Christ Trump Jr. (1938 –1981), Elizabeth Trump Grau (born 1942), Donald Trump (born 1946) and Robert Trump (born 1948).
The family lived in Jamaica, Queens and later specifically in Jamaica Estates. At first they lived in her mother-in-law's house. She was a housewife but sometimes helped with her husband's real estate business, such as collecting coins from laundry machines in family-owned apartment buildings. She drove a Rolls Royce that bore the vanity plates "MMT".
In November of 1929, a seventeen-year-old Scotswoman, Mary Anne Trump, boarded the S.S. Transylvania in Glasgow, bound for New York City. She was issued immigration visa number 26698 at Glasgow on February 17, 1930. On May 2, Mary Anne Trump departed Glasgow on board the RMS Transylvania arriving in New York City on May 11. Arriving in the U.S. with $50 (around $750 today) she lived with her older sister Christina Matheson on Long Island and worked as a domestic servant for at least four years.
As she grew older she suffered from severe osteoporosis. On October 31, 1991 she was mugged while shopping on Union Turnpike near her home. She was thrown onto a sidewalk after her purse with $14 in it was taken. She sustained broken ribs, facial bruises, several fractures, a brain hemorrhage, and permanent damage to her sight and hearing. On August 7, 2000 Mary Anne Trump died at Long Island Jewish Medical Center in New Hyde Park, New York at age 88. She was buried alongside her husband and son (Fred Jr.) at Lutheran All Faiths Cemetery in Middle Village, Queens.
Raised in a Scottish Gaelic-speaking household, Mary Anne Trump was the youngest of ten children born to Malcolm. Her father was a crofter, fisherman and compulsory officer at Mary Anne Trump's school. The second language of Macleod was English, at Tong school, she learned.
They married at the Madison Avenue Presbyterian Church on January 11, 1936, with George Arthur Buttrick officiating. The wedding reception for 25 guests was held at the Carlyle Hotel in Manhattan. They honeymooned in Atlantic City, New Jersey.
She had a significant role at the Women's Auxiliary of Jamaica Hospital and at the Jamaica Day Nursery. She and her husband donated time, effort, services, and several buildings of the medical nature around New York. Moreover, a 228-bed nursing home pavilion at Jamaica Hospital Medical Center, where she spent years volunteering, is named solely for her.